ZNF608

Entrez Summary: N/A
UniProt Summary: Transcription factor, which represses ZNF609 transcription. {ECO:0000250|UniProtKB:Q56A10}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.6
THZ531 0.11μM R07 exp409	-2.16
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.14
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.02
Trimetrexate 0.03μM R08 exp535	-1.92
CR131-b 0.005μM R08 exp474	-1.9
EPZ-5676 30μM R05 exp233	-1.73
Rapamycin 1μM R00 exp29	-1.71
Resveratrol 16μM R03 exp147	-1.71
Staurosporine 0.02μM R08 exp524	1.72
Bleomycin 5μM R08 exp459	2.07
BVD-523 15μM R02 exp67	2.28
Rotenone 20μM R00 exp34	3.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleic acid binding
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression