ZNF639

Gene Information

Official Symbol: ZNF639
Official Name: zinc finger protein 639
Aliases and Previous Symbols: N/A
Entrez ID: 51193
UniProt: Q9UID6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds DNA and may function as a transcriptional repressor. {ECO:0000269|PubMed:16182284}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16367
Expression level (log2 read counts): 6.34

Expression Distribution

Screen	Score
Pyridostatin 4μM R05 exp240	-1.88
39°C R06 exp303	-1.77
Mitomycin-C 0.06μM R08 exp503	-1.73
CoCl2 18μM R07 exp346	1.91

negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of viral transcription
positive regulation of viral transcription
protein self-association
regulation of viral transcription
modification by host of symbiont morphology or physiology
interaction with symbiont
viral entry into host cell
negative regulation of viral process
entry into host cell
entry into host
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
modification of morphology or physiology of other organism
interaction with host
positive regulation of cell growth
viral life cycle
regulation of viral process
negative regulation of multi-organism process
transcription regulatory region DNA binding
regulation of symbiosis, encompassing mutualism through parasitism
positive regulation of growth
regulation of cell growth
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of multi-organism process
regulation of growth
DNA-binding transcription factor activity
viral process
regulation of multi-organism process
symbiotic process
interspecies interaction between organisms
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process