ZNF674

Entrez Summary: This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010].
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 45/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	1/26
bone	3/26
breast	4/30
central nervous system	5/49
cervix	0/4
colorectal	3/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	2/18
liver	2/19
lung	2/72
lymphocyte	1/16
ovary	1/25
pancreas	0/22
peripheral nervous system	2/15
plasma cell	0/12
prostate	1/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	3/28
uterus	1/5

Expression Distribution

KRAB
zf-C2H2

negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression