ZNF703

Gene Information

Official Symbol: ZNF703
Official Name: zinc finger protein 703
Aliases and Previous Symbols: N/A
Entrez ID: 80139
UniProt: Q9H7S9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. {ECO:0000269|PubMed:21328542, ECO:0000269|PubMed:21337521}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15225
Expression level (log2 read counts): 2.31

Expression Distribution

positive regulation of mammary gland epithelial cell proliferation
negative regulation of homotypic cell-cell adhesion
regulation of mammary gland epithelial cell proliferation
mammary gland epithelial cell differentiation
regulation of homotypic cell-cell adhesion
cellular response to estradiol stimulus
adherens junction assembly
repressing transcription factor binding
positive regulation of epithelial to mesenchymal transition
mammary gland epithelium development
adherens junction organization
regulation of epithelial to mesenchymal transition
nuclear matrix
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
mammary gland development
response to estradiol
cell junction assembly
negative regulation of cell-cell adhesion
positive regulation of epithelial cell proliferation
nucleic acid binding
cell junction organization
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
negative regulation of cell adhesion
regulation of canonical Wnt signaling pathway
regulation of epithelial cell proliferation
regulation of Wnt signaling pathway
regulation of cell-cell adhesion
gland development
positive regulation of cell migration
cellular response to lipid
positive regulation of cell motility
positive regulation of cellular component movement
cellular response to organic cyclic compound
positive regulation of locomotion
protein-containing complex
cellular response to hormone stimulus
epithelial cell differentiation
regulation of cell adhesion