ZNHIT1 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNHIT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNHIT1
  * **<color #00a2e8>Official Name</color>**: zinc finger HIT-type containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10467|10467]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43257|O43257]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNHIT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNHIT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618617|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity. {ECO:0000269|PubMed:17380123, ECO:0000269|PubMed:17892483}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-HIT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swr1 complex|
|nucleosome binding|
|regulation of histone deacetylation|
|regulation of protein deacetylation|
|histone exchange|
|ATP-dependent chromatin remodeling|
|histone deacetylase binding|
|regulation of histone modification|
|nucleosome organization|
|chromatin remodeling|
|regulation of chromatin organization|
|protein-DNA complex subunit organization|
|regulation of chromosome organization|
|chromatin organization|
|chromosome organization|
|regulation of organelle organization|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.27|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-2.19|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.08|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.97|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.96|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.92|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.92|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.83|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.81|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.77|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.76|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.74|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.71|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.71|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.7|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.7|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.02|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.02|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.42|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.492|
|[[:human genes:g:gemin7|GEMIN7]]|0.477|
|[[:human genes:n:n6amt1|N6AMT1]]|0.472|
|[[:human genes:t:ten1|TEN1]]|0.468|
|[[:human genes:c:c11orf57|C11orf57]]|0.454|
|[[:human genes:e:eif3f|EIF3F]]|0.452|
|[[:human genes:k:kdm8|KDM8]]|0.447|
|[[:human genes:m:mars|MARS]]|0.446|
|[[:human genes:t:tpi1|TPI1]]|0.441|
|[[:human genes:p:pgm3|PGM3]]|0.44|
|[[:human genes:u:uap1|UAP1]]|0.439|
|[[:human genes:s:slc25a26|SLC25A26]]|0.436|
|[[:human genes:t:thg1l|THG1L]]|0.434|
|[[:human genes:r:rabggtb|RABGGTB]]|0.433|
|[[:human genes:g:gemin6|GEMIN6]]|0.429|
|[[:human genes:r:rpp21|RPP21]]|0.419|
|[[:human genes:a:atm|ATM]]|0.419|
|[[:human genes:a:adsl|ADSL]]|0.416|
|[[:human genes:s:srp14|SRP14]]|0.411|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.411|
|[[:human genes:p:pmm2|PMM2]]|0.411|
|[[:human genes:s:sec61g|SEC61G]]|0.41|
|[[:human genes:e:eno1|ENO1]]|0.409|
|[[:human genes:s:snapc5|SNAPC5]]|0.407|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.407|
|[[:human genes:u:utp23|UTP23]]|0.407|
|[[:human genes:c:cxorf56|CXorf56]]|0.405|
|[[:human genes:r:rpe|RPE]]|0.404|
|[[:human genes:c:c15orf41|C15orf41]]|0.402|
|[[:human genes:p:ppcs|PPCS]]|0.401|
|[[:human genes:l:lsm10|LSM10]]|0.401|
|[[:human genes:t:thoc3|THOC3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5716
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNHIT1 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>