ZNHIT1

Entrez Summary: N/A
UniProt Summary: Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity. {ECO:0000269|PubMed:17380123, ECO:0000269|PubMed:17892483}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thalidomide 20μM R07 exp406	-2.27
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.19
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.08
Ribavirin 10μM R01 exp52	-1.97
DABN 2μM R00 exp16	-1.96
IU1-C 25μM R04 exp183	-1.92
Vinorelbine 0.001μM R05 exp249	-1.92
UM131593 0.2μM R03 exp106	-1.86
Cryptotanshinone 12μM R05 exp227	-1.83
Selumetinib 20μM R02 exp81	-1.81
A-769662 20μM R07 exp331	-1.77
BAY-598 4μM R05 exp220	-1.76
Doxycycline 10μM R00 exp18	-1.76
Rifampicin 1μM R00 exp31	-1.74
BI-2536 0.001μM R01 exp41	-1.71
Nifuroxazide 1μM R01 exp51	-1.71
UM131593 0.1μM R01 exp58	-1.7
Lead acetate 2000μM R08 exp498 no dilution day6	1.7
Aphidicolin 0.4μM R08 exp440	2.02
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.02
Cannabidiol 20μM R08 exp466	2.42
Hippuristanol 0.12μM R08 exp488	2.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Swr1 complex
nucleosome binding
regulation of histone deacetylation
regulation of protein deacetylation
histone exchange
ATP-dependent chromatin remodeling
histone deacetylase binding
regulation of histone modification
nucleosome organization
chromatin remodeling
regulation of chromatin organization
protein-DNA complex subunit organization
regulation of chromosome organization
chromatin organization
chromosome organization
regulation of organelle organization
regulation of protein modification process
protein-containing complex subunit organization