ZWILCH [The Human Chemical-Genetic Interaction Map Project]

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======= ZWILCH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZWILCH
  * **<color #00a2e8>Official Name</color>**: zwilch kinetochore protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55055|55055]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H900|Q9H900]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZWILCH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZWILCH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609984|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). {ECO:0000269|PubMed:15824131}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2352|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RZZ complex|
|kinetochore|
|condensed chromosome kinetochore|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle|
|cell division|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|cell cycle process|
|regulation of cell cycle|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.77|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.74|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.72|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.25|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.23|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.01|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.86|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.77|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.76|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.75|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.85|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.95|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.34|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3.64|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.93|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|4.08|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|4.31|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|4.86|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.93|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|5.08|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|5.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kntc1|KNTC1]]|0.793|
|[[:human genes:z:zw10|ZW10]]|0.776|
|[[:human genes:t:trip13|TRIP13]]|0.762|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.735|
|[[:human genes:m:mad1l1|MAD1L1]]|0.721|
|[[:human genes:m:mad2l1|MAD2L1]]|0.718|
|[[:human genes:b:bub1b|BUB1B]]|0.698|
|[[:human genes:b:bub3|BUB3]]|0.684|
|[[:human genes:r:rbm14|RBM14]]|0.648|
|[[:human genes:f:fntb|FNTB]]|0.558|
|[[:human genes:c:cdc20|CDC20]]|0.525|
|[[:human genes:f:fnta|FNTA]]|0.493|
|[[:human genes:c:ccnb1|CCNB1]]|0.486|
|[[:human genes:d:ddx20|DDX20]]|0.438|
|[[:human genes:c:cenpe|CENPE]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4892
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZWILCH Expression in NALM6 Cells: 6.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>