ZWILCH

Entrez Summary: N/A
UniProt Summary: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). {ECO:0000269|PubMed:15824131}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-2.77
Vincristine 0.0005μM R04 exp190	-2.74
Mdivi-1 15μM R05 exp217	-2.72
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.25
2-Methoxyestradiol 0.55μM R07 exp310	-2.23
Genistein 15μM R07 exp360	-2.01
BVD-523 15μM R02 exp67	-1.86
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.77
Taxol 0.004μM R03 exp103	-1.76
Colchicine 0.009μM R05 exp215	-1.75
Staurosporine 0.02μM R08 exp524	1.85
Cryptotanshinone 12μM R05 exp227	1.95
Nocodazole 0.2μM R02 exp64	3.34
HMS-I1 10μM R06 exp256	3.64
Vinblastine 0.015μM R05 exp208	3.93
Nocodazole 0.2μM R00 exp24	4.08
Nocodazole 0.1μM R03 exp94	4.31
DABN racemic mixture R03 exp93	4.86
SB743921 0.001μM R05 exp244	4.93
Rotenone 2μM R00 exp33	5.08
R-DABN 8μM R03 exp111	5.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RZZ complex
kinetochore
condensed chromosome kinetochore
mitotic cell cycle checkpoint
cell cycle checkpoint
negative regulation of mitotic cell cycle
cell division
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
cell cycle process
regulation of cell cycle
cell cycle