ZZZ3 [The Human Chemical-Genetic Interaction Map Project]

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======= ZZZ3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZZZ3
  * **<color #00a2e8>Official Name</color>**: zinc finger ZZ-type containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26009|26009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYH5|Q8IYH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZZZ3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZZZ3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619892|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ada2/Gcn5/Ada3 transcription activator complex|
|zinc ion binding|
|nucleolus|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.26|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.92|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.88|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.87|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.72|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.75|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.78|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.79|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.8|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.81|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.86|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.99|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.33|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.36|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.4|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.49|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.57|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.59|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.66|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.94|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tada2a|TADA2A]]|0.66|
|[[:human genes:y:yeats2|YEATS2]]|0.589|
|[[:human genes:d:dohh|DOHH]]|0.529|
|[[:human genes:m:mlst8|MLST8]]|0.502|
|[[:human genes:t:thg1l|THG1L]]|0.499|
|[[:human genes:f:faf2|FAF2]]|0.49|
|[[:human genes:c:casp9|CASP9]]|0.489|
|[[:human genes:u:ubqln1|UBQLN1]]|0.486|
|[[:human genes:p:plaa|PLAA]]|0.482|
|[[:human genes:g:gtf3a|GTF3A]]|0.482|
|[[:human genes:m:mbip|MBIP]]|0.48|
|[[:human genes:b:bak1|BAK1]]|0.479|
|[[:human genes:r:rptor|RPTOR]]|0.478|
|[[:human genes:c:csrp2bp|CSRP2BP]]|0.475|
|[[:human genes:v:vdac2|VDAC2]]|0.475|
|[[:human genes:h:heatr3|HEATR3]]|0.473|
|[[:human genes:w:wdr5|WDR5]]|0.47|
|[[:human genes:d:dph6|DPH6]]|0.466|
|[[:human genes:r:rad23b|RAD23B]]|0.452|
|[[:human genes:w:wdr24|WDR24]]|0.449|
|[[:human genes:w:wdr59|WDR59]]|0.445|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.443|
|[[:human genes:e:eif4g1|EIF4G1]]|0.442|
|[[:human genes:m:march5|MARCH5]]|0.438|
|[[:human genes:r:romo1|ROMO1]]|0.437|
|[[:human genes:a:apaf1|APAF1]]|0.436|
|[[:human genes:g:gmppb|GMPPB]]|0.433|
|[[:human genes:t:trmt10a|TRMT10A]]|0.425|
|[[:human genes:s:sbds|SBDS]]|0.424|
|[[:human genes:a:alg1|ALG1]]|0.423|
|[[:human genes:p:pdpk1|PDPK1]]|0.419|
|[[:human genes:d:dr1|DR1]]|0.417|
|[[:human genes:s:serf2|SERF2]]|0.415|
|[[:human genes:r:rnmt|RNMT]]|0.413|
|[[:human genes:k:kdsr|KDSR]]|0.413|
|[[:human genes:d:dph5|DPH5]]|0.411|
|[[:human genes:p:pmm2|PMM2]]|0.41|
|[[:human genes:e:eif4e|EIF4E]]|0.408|
|[[:human genes:d:ddx39a|DDX39A]]|0.405|
|[[:human genes:d:dpagt1|DPAGT1]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZZZ3 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>