ZZZ3

Entrez Summary: N/A
UniProt Summary: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. {ECO:0000269|PubMed:19103755}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Colchicine 0.009μM R05 exp215	-2.26
Vincristine 0.0005μM R04 exp190	-1.92
Cadmium 60μM R08 exp462	-1.88
Rapamycin 1μM R00 exp29	-1.87
BML-284 0.09μM R08 exp460	-1.72
UM0129480 7μM R02 exp85	1.74
Bafilomycin-A1 0.009μM R08 exp454	1.75
Benzoate 20000μM R08 exp456	1.78
BVD-523 15μM R02 exp67	1.79
Monensin 0.3μM R08 exp507	1.8
DABN racemic mixture R03 exp93	1.81
3-Bromopyruvate 7μM R04 exp175	1.86
Bortezomib 0.005μM R00 exp6	1.86
Staurosporine 0.02μM R08 exp524	1.99
AICAR 240μM R05 exp211	2.33
5-Fluorouracil 20μM R00 exp2	2.36
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.4
Olaparib 4μM R08 exp512	2.49
Actinomycin-D 0.001μM R00 exp3	2.57
THZ531 0.225μM R08 exp444	2.59
Aphidicolin 0.4μM R08 exp440	2.66
Nifuroxazide 5μM R03 exp102	2.7
AICAR 240μM R03 exp116	2.78
MS023 2μM R03 exp134	2.94
MS023 7μM R03 exp135	3.97

Global Fraction of Cell Lines Where Essential: 3/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ada2/Gcn5/Ada3 transcription activator complex
zinc ion binding
nucleolus
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific