Entrez Summary: In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated.[provided by RefSeq, Mar 2009].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
ABC tran
ABC2 membrane 3
GO Terms
lipid transporter activity
ATPase-coupled transmembrane transporter activity
azurophil granule membrane
secretory granule membrane
ATPase activity
lipid transport
lipid localization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
intracellular membrane-bounded organelle
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
ion transmembrane transport
secretion by cell
export from cell
cell activation
immune effector process
secretion
transmembrane transport
ion transport
ATP binding
immune response
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)