Entrez Summary: This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009].
UniProt Summary: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}.
Pfam DomainsGO Terms
Pfam Domains
SAM 1
KH 1
SAM 2
GO Terms
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
regulation of canonical Wnt signaling pathway
regulation of Wnt signaling pathway
pattern specification process
heart development
circulatory system development
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
RNA binding
negative regulation of response to stimulus
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)