C6orf57
Gene Information
- Official Symbol: SDHAF4
- Official Name: succinate dehydrogenase complex assembly factor 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 135154
- UniProt: Q5VUM1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3207
- Expression level (log2 read counts): 2.89
C6ORF57 Expression in NALM6 Cells: 2.89
