CACNB3
Gene Information
- Official Symbol: CACNB3
- Official Name: calcium voltage-gated channel auxiliary subunit beta 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 784
- UniProt: P54284
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| VGCC beta4Aa N |
| Guanylate kin |
GO Terms
| regulation of detection of mechanical stimulus involved in sensory perception of touch |
| negative regulation of detection of mechanical stimulus involved in sensory perception of touch |
| regulation of membrane hyperpolarization |
| calcium ion transmembrane transport via high voltage-gated calcium channel |
| positive regulation of high voltage-gated calcium channel activity |
| regulation of membrane repolarization during action potential |
| response to oxygen-glucose deprivation |
| cellular response to oxygen-glucose deprivation |
| high voltage-gated calcium channel activity |
| positive regulation of voltage-gated calcium channel activity |
| L-type voltage-gated calcium channel complex |
| detection of mechanical stimulus involved in sensory perception of pain |
| negative regulation of voltage-gated calcium channel activity |
| regulation of high voltage-gated calcium channel activity |
| negative regulation of nervous system process |
| voltage-gated calcium channel complex |
| positive regulation of excitatory postsynaptic potential |
| detection of mechanical stimulus involved in sensory perception |
| positive regulation of protein targeting to membrane |
| regulation of membrane repolarization |
| regulation of voltage-gated calcium channel activity |
| negative regulation of calcium ion transmembrane transporter activity |
| regulation of protein targeting to membrane |
| calcium channel regulator activity |
| positive regulation of calcium ion transmembrane transporter activity |
| negative regulation of calcium ion transmembrane transport |
| modulation of excitatory postsynaptic potential |
| regulation of sensory perception |
| voltage-gated calcium channel activity |
| neuromuscular junction development |
| negative regulation of cation channel activity |
| detection of mechanical stimulus |
| regulation of action potential |
| membrane depolarization |
| negative regulation of calcium ion transport |
| positive regulation of nervous system process |
| positive regulation of cation channel activity |
| positive regulation of calcium ion transmembrane transport |
| negative regulation of ion transmembrane transporter activity |
| calcium ion transport into cytosol |
| sensory perception of pain |
| negative regulation of transporter activity |
| regulation of protein targeting |
| negative regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transporter activity |
| cytosolic calcium ion transport |
| cardiac conduction |
| negative regulation of ion transmembrane transport |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| negative regulation of transmembrane transport |
| detection of external stimulus |
| positive regulation of calcium ion transport |
| detection of abiotic stimulus |
| positive regulation of protein localization to membrane |
| multicellular organismal signaling |
| regulation of nervous system process |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| positive regulation of synaptic transmission |
| positive regulation of intracellular protein transport |
| positive regulation of ion transmembrane transport |
| sensory perception of mechanical stimulus |
| regulation of cation channel activity |
| T cell receptor signaling pathway |
| protein localization to plasma membrane |
| regulation of protein localization to membrane |
| cellular response to decreased oxygen levels |
| calcium ion transmembrane transport |
| positive regulation of transmembrane transport |
| positive regulation of intracellular transport |
| response to mechanical stimulus |
| cellular response to oxygen levels |
| protein localization to cell periphery |
| regulation of intracellular protein transport |
| cellular response to nutrient levels |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| cellular response to extracellular stimulus |
| synapse organization |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| antigen receptor-mediated signaling pathway |
| divalent metal ion transport |
| divalent inorganic cation transport |
| apical plasma membrane |
| positive regulation of cellular protein localization |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| cellular response to external stimulus |
| regulation of intracellular transport |
| response to decreased oxygen levels |
| negative regulation of response to external stimulus |
| response to oxygen levels |
| regulation of metal ion transport |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| positive regulation of protein transport |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of cellular protein localization |
| detection of stimulus involved in sensory perception |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| regulation of system process |
| immune response-regulating signaling pathway |
| cation transmembrane transport |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| detection of stimulus |
| regulation of ion transport |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| ion homeostasis |
| cation transport |
| positive regulation of immune response |
| cellular homeostasis |
| regulation of cellular localization |
| ion transmembrane transport |
| sensory perception |
| positive regulation of transport |
| regulation of protein localization |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| transmembrane transport |
| ion transport |
| nervous system process |
| cellular protein localization |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC0649 7μM R03 exp150 | -1.76 |
| FK-506 30μM R07 exp359 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 17/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 3/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8377
- Expression level (log2 read counts): 4.06
Expression Distribution
CACNB3 Expression in NALM6 Cells: 4.06
