CIDEB
Gene Information
- Official Symbol: CIDEB
- Official Name: cell death inducing DFFA like effector b
- Aliases and Previous Symbols: N/A
- Entrez ID: 27141
- UniProt: Q9UHD4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activates apoptosis.
Pfam Domains GO Terms
Pfam Domains
| CIDE-N |
GO Terms
| activation of cysteine-type endopeptidase activity |
| positive regulation of release of cytochrome c from mitochondria |
| zymogen activation |
| regulation of release of cytochrome c from mitochondria |
| execution phase of apoptosis |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| lipid droplet |
| positive regulation of mitochondrion organization |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| protein processing |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| positive regulation of peptidase activity |
| protein maturation |
| regulation of cysteine-type endopeptidase activity |
| apoptotic signaling pathway |
| positive regulation of proteolysis |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| apoptotic process |
| programmed cell death |
| identical protein binding |
| cell death |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of hydrolase activity |
| regulation of organelle organization |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5145
- Expression level (log2 read counts): 4.76
Expression Distribution
CIDEB Expression in NALM6 Cells: 4.76
