CTNNBIP1
Gene Information
- Official Symbol: CTNNBIP1
- Official Name: catenin beta interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 56998
- UniProt: Q9NSA3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.
Pfam Domains GO Terms
Pfam Domains
| ICAT |
GO Terms
| regulation of vascular permeability involved in acute inflammatory response |
| negative regulation of transcription initiation from RNA polymerase II promoter |
| negative regulation of DNA-templated transcription, initiation |
| negative regulation of mesenchymal cell proliferation |
| positive regulation of monocyte differentiation |
| armadillo repeat domain binding |
| beta-catenin destruction complex |
| regulation of monocyte differentiation |
| regulation of transcription initiation from RNA polymerase II promoter |
| regulation of mesenchymal cell proliferation |
| regulation of DNA-templated transcription, initiation |
| regulation of vascular permeability |
| branching involved in ureteric bud morphogenesis |
| negative regulation of smooth muscle cell proliferation |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| negative regulation of DNA binding |
| positive regulation of myeloid leukocyte differentiation |
| positive regulation of osteoblast differentiation |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| acute inflammatory response |
| nephron tubule development |
| renal tubule development |
| beta-catenin binding |
| kidney morphogenesis |
| positive regulation of ossification |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| mesonephros development |
| positive regulation of myeloid cell differentiation |
| nephron epithelium development |
| negative regulation of protein binding |
| regulation of osteoblast differentiation |
| regulation of myeloid leukocyte differentiation |
| nephron development |
| regulation of DNA binding |
| kidney epithelium development |
| negative regulation of protein complex assembly |
| branching morphogenesis of an epithelial tube |
| regulation of smooth muscle cell proliferation |
| positive regulation of leukocyte differentiation |
| morphogenesis of a branching epithelium |
| negative regulation of DNA-binding transcription factor activity |
| morphogenesis of a branching structure |
| vascular process in circulatory system |
| negative regulation of binding |
| positive regulation of hemopoiesis |
| regulation of ossification |
| negative regulation of Wnt signaling pathway |
| anterior/posterior pattern specification |
| regulation of protein binding |
| regulation of myeloid cell differentiation |
| kidney development |
| regulation of leukocyte differentiation |
| renal system development |
| epithelial tube morphogenesis |
| urogenital system development |
| regionalization |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| regulation of Wnt signaling pathway |
| regulation of binding |
| blood circulation |
| circulatory system process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| pattern specification process |
| regulation of protein complex assembly |
| regulation of hemopoiesis |
| inflammatory response |
| tissue morphogenesis |
| tube morphogenesis |
| negative regulation of cell population proliferation |
| negative regulation of cellular component organization |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| epithelium development |
| cell-cell signaling |
| negative regulation of molecular function |
| positive regulation of immune system process |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| AXIN1 | 0.422 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10125
- Expression level (log2 read counts): 1.64
Expression Distribution
CTNNBIP1 Expression in NALM6 Cells: 1.64
