FCGRT

Entrez Summary: N/A
UniProt Summary: Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:7964511}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 0.1μM R01 exp49	-1.87
Nicotinamide 2000μM R01 exp50	-1.84
Lapatinib 5μM R01 exp47	-1.78
Bortezomib 0.05μM R00 exp7	-1.72
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.75
Cytochalasin-B 5μM R07 exp349	1.78
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.85
FK-506 5μM R07 exp358	1.86
FK-506 30μM R07 exp359	1.95
SNS-032 25μM R07 exp401	2.19
Wiskostatin 3μM R07 exp422	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution