GNL2

Entrez Summary: N/A
UniProt Summary: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). {ECO:0000250, ECO:0000269|PubMed:26203195}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	-2.84
Deferoxamine 11μM R07 exp350	-2.07
GSK343 3μM R03 exp124	1.7
Dihydrosphingosine 8μM R08 exp476	1.74
L-74142 5μM R03 exp131	1.99
Heregulin-B 44ng/ml R08 exp486	2.23
Nicotinamide 2000μM R01 exp50	2.24
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.64

Gene	Correlation
UTP3	0.418
TBC1D3H	0.403

Global Fraction of Cell Lines Where Essential: 514/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	18/28
blood	20/28
bone	16/26
breast	23/33
central nervous system	41/56
cervix	4/4
colorectal	13/17
esophagus	8/13
fibroblast	0/1
gastric	9/16
kidney	19/21
liver	15/20
lung	52/75
lymphocyte	12/16
ovary	13/26
pancreas	18/24
peripheral nervous system	13/16
plasma cell	7/15
prostate	1/1
skin	19/24
soft tissue	8/9
thyroid	1/2
upper aerodigestive	14/22
urinary tract	19/29
uterus	4/5

Expression Distribution