GPN1
Gene Information
- Official Symbol: GPN1
- Official Name: GPN-loop GTPase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 11321
- UniProt: Q9HCN4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:20855544, ECO:0000269|PubMed:21768307, ECO:0000305|PubMed:11058119}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 966
- Expression level (log2 read counts): 5.59
GPN1 Expression in NALM6 Cells: 5.59
