GRWD1

Entrez Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
UniProt Summary: Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725). {ECO:0000269|PubMed:25990725}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.001μM R01 exp42	-1.72
Taxol 0.002μM R01 exp54	-1.72

Global Fraction of Cell Lines Where Essential: 416/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	16/28
blood	10/28
bone	12/26
breast	14/33
central nervous system	29/56
cervix	1/4
colorectal	12/17
esophagus	6/13
fibroblast	0/1
gastric	7/16
kidney	15/21
liver	8/20
lung	37/75
lymphocyte	7/16
ovary	17/26
pancreas	15/24
peripheral nervous system	9/16
plasma cell	5/15
prostate	0/1
skin	14/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	12/22
urinary tract	17/29
uterus	5/5

Expression Distribution