HGF
Gene Information
- Official Symbol: HGF
- Official Name: hepatocyte growth factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 3082
- UniProt: P14210
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Trypsin |
| Kringle |
| PAN 1 |
GO Terms
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| myoblast proliferation |
| negative regulation of hydrogen peroxide-mediated programmed cell death |
| mesenchymal-epithelial cell signaling |
| regulation of hydrogen peroxide-mediated programmed cell death |
| regulation of branching involved in salivary gland morphogenesis |
| positive regulation of neuron projection regeneration |
| regulation of tau-protein kinase activity |
| hepatocyte growth factor receptor signaling pathway |
| negative regulation of hydrogen peroxide-induced cell death |
| negative regulation of response to reactive oxygen species |
| cellular response to hepatocyte growth factor stimulus |
| positive regulation of myelination |
| response to hepatocyte growth factor |
| negative regulation of release of cytochrome c from mitochondria |
| negative regulation of cellular response to drug |
| regulation of hydrogen peroxide-induced cell death |
| negative regulation of peptidyl-serine phosphorylation |
| negative regulation of response to drug |
| regulation of neuron projection regeneration |
| hyaluronan metabolic process |
| regulation of response to reactive oxygen species |
| regulation of cellular response to drug |
| positive regulation of interleukin-10 production |
| chemoattractant activity |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of p38MAPK cascade |
| regulation of myelination |
| negative regulation of interleukin-6 production |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of response to oxidative stress |
| positive chemotaxis |
| regulation of release of cytochrome c from mitochondria |
| regulation of interleukin-10 production |
| negative regulation of mitochondrion organization |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of morphogenesis of a branching structure |
| positive regulation of osteoblast differentiation |
| regulation of oxidative stress-induced cell death |
| positive regulation of nervous system process |
| positive regulation of DNA biosynthetic process |
| platelet alpha granule lumen |
| epithelial to mesenchymal transition |
| animal organ regeneration |
| regulation of cellular response to oxidative stress |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of autophagy |
| positive regulation of ossification |
| regulation of response to oxidative stress |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| epithelial cell proliferation |
| negative regulation of cysteine-type endopeptidase activity |
| regulation of response to drug |
| negative regulation of extrinsic apoptotic signaling pathway |
| mucopolysaccharide metabolic process |
| regulation of DNA biosynthetic process |
| regulation of osteoblast differentiation |
| regulation of phosphatidylinositol 3-kinase signaling |
| liver development |
| hepaticobiliary system development |
| platelet degranulation |
| regulation of peptidyl-serine phosphorylation |
| regulation of nervous system process |
| negative regulation of inflammatory response |
| regulation of interleukin-6 production |
| regulation of extrinsic apoptotic signaling pathway |
| activation of MAPK activity |
| glycosaminoglycan metabolic process |
| mesenchymal cell differentiation |
| regeneration |
| serine-type endopeptidase activity |
| positive regulation of angiogenesis |
| growth factor activity |
| aminoglycan metabolic process |
| positive regulation of protein kinase B signaling |
| regulation of mitochondrion organization |
| regulation of morphogenesis of an epithelium |
| positive regulation of vasculature development |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of ossification |
| positive regulation of DNA metabolic process |
| negative regulation of defense response |
| cell chemotaxis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of protein kinase B signaling |
| mesenchyme development |
| negative regulation of apoptotic signaling pathway |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of cellular catabolic process |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of peptidase activity |
| regulation of animal organ morphogenesis |
| positive regulation of MAP kinase activity |
| negative regulation of cytokine production |
| positive regulation of neuron projection development |
| regulation of angiogenesis |
| negative regulation of catabolic process |
| regulation of vasculature development |
| activation of protein kinase activity |
| regulation of autophagy |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| negative regulation of proteolysis |
| regulation of DNA metabolic process |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| MAPK cascade |
| negative regulation of organelle organization |
| positive regulation of cell projection organization |
| signal transduction by protein phosphorylation |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| gland development |
| regulation of endopeptidase activity |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| positive regulation of neurogenesis |
| protein heterodimerization activity |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell population proliferation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| regulation of system process |
| negative regulation of protein modification process |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cytokine-mediated signaling pathway |
| mitotic cell cycle |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of defense response |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| regulation of cell migration |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of catabolic process |
| negative regulation of cell death |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| localization of cell |
| cell motility |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SNS-032 25μM R07 exp401 | -1.99 |
| 2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 | -1.92 |
| ONC212 0.15μM R08 exp513 | -1.78 |
| Palbociclib 1μM R07 exp382 | -1.71 |
| BS-181 20μM R08 exp461 | 1.87 |
| Rifampicin 1μM R00 exp31 | 2.31 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3094
- Expression level (log2 read counts): -3.35
Expression Distribution
HGF Expression in NALM6 Cells: -3.35
