Entrez Summary: This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, although how brain function is affected remains unknown. [provided by RefSeq, Sep 2011].
UniProt Summary: May play a role in cellular stress response. {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Cupin 4
GO Terms
2-oxoglutarate-dependent dioxygenase activity
oxidation-reduction process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)