INHBA
Gene Information
- Official Symbol: INHBA
- Official Name: inhibin subunit beta A
- Aliases and Previous Symbols: N/A
- Entrez ID: 3624
- UniProt: P08476
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| activin A complex |
| positive regulation of ovulation |
| type II activin receptor binding |
| progesterone secretion |
| inhibin A complex |
| negative regulation of follicle-stimulating hormone secretion |
| regulation of ovulation |
| negative regulation of interferon-gamma biosynthetic process |
| striatal medium spiny neuron differentiation |
| negative regulation of B cell differentiation |
| lipid export from cell |
| inhibin binding |
| hemoglobin biosynthetic process |
| steroid hormone secretion |
| positive regulation of follicle-stimulating hormone secretion |
| regulation of follicle-stimulating hormone secretion |
| positive regulation of gonadotropin secretion |
| luteinization |
| negative regulation of macrophage differentiation |
| negative regulation of gonadotropin secretion |
| hemoglobin metabolic process |
| regulation of gonadotropin secretion |
| endocrine hormone secretion |
| cellular response to follicle-stimulating hormone stimulus |
| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| eyelid development in camera-type eye |
| GABAergic neuron differentiation |
| response to follicle-stimulating hormone |
| cellular response to cholesterol |
| regulation of interferon-gamma biosynthetic process |
| cellular response to gonadotropin stimulus |
| striatum development |
| regulation of macrophage differentiation |
| cellular response to sterol |
| subpallium development |
| activin receptor signaling pathway |
| mesodermal cell differentiation |
| response to cholesterol |
| regulation of B cell differentiation |
| response to gonadotropin |
| positive regulation of erythrocyte differentiation |
| negative regulation of B cell activation |
| response to sterol |
| negative regulation of cytokine biosynthetic process |
| negative regulation of interferon-gamma production |
| peptide hormone binding |
| endodermal cell differentiation |
| transforming growth factor beta receptor binding |
| ovulation cycle process |
| regulation of endocrine process |
| negative regulation of myeloid leukocyte differentiation |
| regulation of erythrocyte differentiation |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| endoderm formation |
| endocrine process |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| positive regulation of extrinsic apoptotic signaling pathway |
| forebrain neuron differentiation |
| ovarian follicle development |
| negative regulation of lymphocyte differentiation |
| SMAD protein signal transduction |
| regulation of pathway-restricted SMAD protein phosphorylation |
| negative regulation of hormone secretion |
| forebrain generation of neurons |
| ovulation cycle |
| mesoderm formation |
| mesoderm morphogenesis |
| hair follicle development |
| hormone secretion |
| skin epidermis development |
| endoderm development |
| molting cycle process |
| hair cycle process |
| negative regulation of myeloid cell differentiation |
| positive regulation of reproductive process |
| erythrocyte differentiation |
| hormone transport |
| cellular response to alcohol |
| hematopoietic progenitor cell differentiation |
| female gonad development |
| erythrocyte homeostasis |
| roof of mouth development |
| molting cycle |
| positive regulation of myeloid cell differentiation |
| hair cycle |
| development of primary female sexual characteristics |
| extrinsic apoptotic signaling pathway |
| hormone activity |
| regulation of interferon-gamma production |
| negative regulation of leukocyte differentiation |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cytokine biosynthetic process |
| myeloid cell homeostasis |
| female sex differentiation |
| formation of primary germ layer |
| regulation of myeloid leukocyte differentiation |
| G1/S transition of mitotic cell cycle |
| odontogenesis |
| cell cycle G1/S phase transition |
| mesoderm development |
| positive regulation of hormone secretion |
| male gonad development |
| development of primary male sexual characteristics |
| negative regulation of hemopoiesis |
| negative regulation of lymphocyte activation |
| cell cycle arrest |
| drug transport |
| regulation of extrinsic apoptotic signaling pathway |
| male sex differentiation |
| gastrulation |
| regulation of reproductive process |
| growth factor activity |
| regulation of lymphocyte differentiation |
| signal release |
| cytokine activity |
| positive regulation of apoptotic signaling pathway |
| negative regulation of leukocyte activation |
| central nervous system neuron differentiation |
| negative regulation of cell growth |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| homeostasis of number of cells |
| negative regulation of secretion by cell |
| regulation of B cell activation |
| gonad development |
| development of primary sexual characteristics |
| myeloid cell differentiation |
| regulation of myeloid cell differentiation |
| negative regulation of secretion |
| response to alcohol |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of growth |
| telencephalon development |
| sex differentiation |
| regulation of hormone secretion |
| mitotic cell cycle phase transition |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| rhythmic process |
| cell cycle phase transition |
| apoptotic signaling pathway |
| lipid transport |
| camera-type eye development |
| lipid localization |
| cellular process involved in reproduction in multicellular organism |
| eye development |
| visual system development |
| sensory system development |
| skin development |
| forebrain development |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| epidermis development |
| regulation of cell growth |
| reproductive structure development |
| reproductive system development |
| positive regulation of secretion |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| negative regulation of transport |
| protein heterodimerization activity |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| cellular response to lipid |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| sensory organ development |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| negative regulation of cell cycle |
| regulation of system process |
| mitotic cell cycle process |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| mitotic cell cycle |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| brain development |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of multi-organism process |
| head development |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| response to lipid |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| cell cycle process |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| export from cell |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell death |
| negative regulation of protein metabolic process |
| epithelium development |
| cell-cell signaling |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| defense response |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ribavirin 10μM R01 exp52 | 1.77 |
| Rotenone 2μM R00 exp33 | 1.84 |
| SB743921 0.001μM R05 exp244 | 1.96 |
| DABN racemic mixture R03 exp93 | 2.2 |
| R-DABN 8μM R03 exp111 | 2.58 |
| Nocodazole 0.1μM R03 exp94 | 3.23 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16952
- Expression level (log2 read counts): 0.15
Expression Distribution
INHBA Expression in NALM6 Cells: 0.15
