LHX5
Gene Information
- Official Symbol: LHX5
- Official Name: LIM homeobox 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 64211
- UniProt: Q9H2C1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.
Pfam Domains GO Terms
Pfam Domains
| LIM |
| Homeobox |
GO Terms
| cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation |
| positive regulation of cerebellar granule cell precursor proliferation |
| cerebellar Purkinje cell differentiation |
| cerebellar Purkinje cell layer formation |
| regulation of cerebellar granule cell precursor proliferation |
| spinal cord association neuron differentiation |
| cerebellar Purkinje cell layer morphogenesis |
| cell differentiation in hindbrain |
| cerebellar cortex formation |
| dorsal spinal cord development |
| cerebellar Purkinje cell layer development |
| cell proliferation in forebrain |
| cerebellar cortex morphogenesis |
| cerebellum morphogenesis |
| hindbrain morphogenesis |
| cerebellar cortex development |
| forebrain neuron differentiation |
| positive regulation of neural precursor cell proliferation |
| cell differentiation in spinal cord |
| forebrain generation of neurons |
| neural precursor cell proliferation |
| hippocampus development |
| regulation of neural precursor cell proliferation |
| cerebellum development |
| spinal cord development |
| limbic system development |
| metencephalon development |
| hindbrain development |
| pallium development |
| central nervous system neuron differentiation |
| telencephalon development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| forebrain development |
| positive regulation of nervous system development |
| cell population proliferation |
| brain development |
| head development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| central nervous system development |
| neuron differentiation |
| cell-cell signaling |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of developmental process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Losmapimod 1μM R07 exp376 | -1.79 |
| Benzoate 10000μM R08 exp455 | 2.03 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15140
- Expression level (log2 read counts): -2.69
Expression Distribution
LHX5 Expression in NALM6 Cells: -2.69
