MDGA1
Gene Information
- Official Symbol: MDGA1
- Official Name: MAM domain containing glycosylphosphatidylinositol anchor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 266727
- UniProt: Q8NFP4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that is expressed predominantly in the developing nervous system. In addition to possessing several cell adhesion molecule-like domains, the mature protein has six Ig-like domains, a single fibronectin type III domain, a MAM domain and a C-terminal GPI-anchoring site. Studies in other mammals suggest this protein plays a role in cell adhesion, migration, and axon guidance and, in the developing brain, neuronal migration. In humans, this gene is associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016].
- UniProt Summary: Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2. {ECO:0000250, ECO:0000269|PubMed:23248271}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8262
- Expression level (log2 read counts): 0.69
MDGA1 Expression in NALM6 Cells: 0.69
