MTHFD1L

• Official Symbol: MTHFD1L
• Official Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
• Aliases and Previous Symbols: N/A
• Entrez ID: 25902
• UniProt: Q6UB35
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene is involved in the synthesis of tetrahydrofolate (THF) in the mitochondrion. THF is important in the de novo synthesis of purines and thymidylate and in the regeneration of methionine from homocysteine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011].
• UniProt Summary: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 5693
• Expression level (log2 read counts): 6.86

Expression Distribution

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MTHFD1L Expression in NALM6 Cells: 6.86