Pfam Domains GO Terms
| TLD |
| GRAM |
| LysM |
| negative regulation of peptidyl-cysteine S-nitrosylation |
| regulation of peptidyl-cysteine S-nitrosylation |
| negative regulation of oxidative stress-induced neuron death |
| nuclear hormone receptor binding |
| regulation of oxidative stress-induced neuron death |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of response to oxidative stress |
| regulation of oxidative stress-induced cell death |
| nuclear receptor transcription coactivator activity |
| regulation of cellular response to oxidative stress |
| regulation of response to oxidative stress |
| intracellular |
| negative regulation of neuron death |
| regulation of neuron death |
| negative regulation of protein modification process |
| regulation of cellular response to stress |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| positive regulation of transcription by RNA polymerase II |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| 3-Bromopyruvate 7μM R04 exp175 | -1.84 |
| Gene | Correlation |
|---|---|
| RRM1 | 0.438 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution