Entrez Summary: This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008].
UniProt Summary: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.
Pfam DomainsGO Terms
Pfam Domains
NIDO
Ldl recept b
EGF CA
G2F
cEGF
Thyroglobulin 1
EGF 3
GO Terms
laminin-1 binding
glomerular basement membrane development
proteoglycan binding
basement membrane organization
laminin binding
cell periphery
glomerulus development
collagen binding
basement membrane
positive regulation of cell-substrate adhesion
nephron development
cell-matrix adhesion
extracellular matrix structural constituent
cell-substrate adhesion
regulation of cell-substrate adhesion
kidney development
renal system development
urogenital system development
extracellular matrix organization
collagen-containing extracellular matrix
extracellular structure organization
positive regulation of cell adhesion
regulation of cell adhesion
calcium ion binding
cell adhesion
biological adhesion
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)