NRBP1

Entrez Summary: N/A
UniProt Summary: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. {ECO:0000269|PubMed:11956649, ECO:0000269|PubMed:15084397, ECO:0000303|PubMed:11956649}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nicotine 3000μM R08 exp510	-1.71
39°C R06 exp303	1.7
Geldanamycin 0.01μM R05 exp235	1.7
Docetaxel 0.002μM R01 exp45	1.85
Vincristine 0.0005μM R04 exp190	1.96
Sulforaphane 9μM R08 exp526 no dilution day6	2.03
MLN-4924 0.2μM R00 exp21	2.1
I-BRD9 4μM R07 exp365	2.19
Phenformin 20μM R05 exp212	2.26
Dinaciclib 0.007μM R07 exp355	2.4
3-Bromopyruvate 7μM R04 exp175	2.85

Global Fraction of Cell Lines Where Essential: 413/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	15/28
bone	13/26
breast	18/33
central nervous system	25/56
cervix	2/4
colorectal	11/17
esophagus	9/13
fibroblast	0/1
gastric	9/16
kidney	8/21
liver	12/20
lung	37/75
lymphocyte	9/16
ovary	10/26
pancreas	19/24
peripheral nervous system	7/16
plasma cell	13/15
prostate	1/1
skin	14/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	11/22
urinary tract	23/29
uterus	1/5

Expression Distribution