OXR1
Gene Information
- Official Symbol: OXR1
- Official Name: oxidation resistance 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55074
- UniProt: Q8N573
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| LysM |
| GRAM |
| TLD |
GO Terms
| negative regulation of peptidyl-cysteine S-nitrosylation |
| regulation of peptidyl-cysteine S-nitrosylation |
| cellular response to hydroperoxide |
| negative regulation of oxidative stress-induced neuron death |
| response to hydroperoxide |
| regulation of oxidative stress-induced neuron death |
| adult walking behavior |
| walking behavior |
| neuron apoptotic process |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of response to oxidative stress |
| neuron death |
| regulation of oxidative stress-induced cell death |
| regulation of cellular response to oxidative stress |
| adult locomotory behavior |
| regulation of response to oxidative stress |
| oxidoreductase activity |
| adult behavior |
| negative regulation of neuron apoptotic process |
| locomotory behavior |
| negative regulation of neuron death |
| regulation of neuron apoptotic process |
| cellular response to oxidative stress |
| regulation of neuron death |
| response to oxidative stress |
| behavior |
| negative regulation of protein modification process |
| intracellular membrane-bounded organelle |
| regulation of cellular response to stress |
| molecular function |
| nucleolus |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| oxidation-reduction process |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| cell death |
| negative regulation of protein metabolic process |
| mitochondrion |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of cell death |
| cellular response to stress |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 0.1μM R06 exp260 | 1.78 |
| Lapatinib 5μM R01 exp47 | 1.83 |
| BI-6727 0.001μM R01 exp42 | 2.11 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15945
- Expression level (log2 read counts): 4.77
Expression Distribution
OXR1 Expression in NALM6 Cells: 4.77
