PABPC1L
Gene Information
- Official Symbol: PABPC1L
- Official Name: poly(A) binding protein cytoplasmic 1 like
- Aliases and Previous Symbols: N/A
- Entrez ID: 80336
- UniProt: Q4VXU2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PABP |
| RRM 1 |
GO Terms
| chromatin-mediated maintenance of transcription |
| oocyte maturation |
| poly(A) binding |
| nucleus localization |
| mRNA polyadenylation |
| poly(U) RNA binding |
| RNA polyadenylation |
| oocyte development |
| oocyte differentiation |
| positive regulation of gene expression, epigenetic |
| cytoplasmic stress granule |
| chromatin organization involved in regulation of transcription |
| mRNA 3-UTR binding |
| oogenesis |
| mRNA 3-end processing |
| female gamete generation |
| RNA 3-end processing |
| anatomical structure maturation |
| ribonucleoprotein complex |
| cell maturation |
| chromatin remodeling |
| regulation of gene expression, epigenetic |
| developmental maturation |
| germ cell development |
| cellular process involved in reproduction in multicellular organism |
| mRNA processing |
| organelle localization |
| developmental process involved in reproduction |
| gamete generation |
| mRNA metabolic process |
| chromatin organization |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| RNA processing |
| multi-organism reproductive process |
| chromosome organization |
| RNA binding |
| reproductive process |
| reproduction |
| positive regulation of transcription, DNA-templated |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Metformin 40μM R03 exp132 | -2.27 |
| OICR-9429 10μM R03 exp142 | -2.01 |
| SB202190 10μM R03 exp148 | -2 |
| Sulforaphane 9μM R08 exp526 no dilution day6 | -1.94 |
| Golgicide-A 2μM R03 exp121 | -1.91 |
| Nifuroxazide 5μM R03 exp102 | -1.87 |
| SB203580 25μM R03 exp149 | -1.87 |
| UMK57 0.6μM R03 exp107 | -1.81 |
| NFN1 1μM R03 exp100 | -1.76 |
| PFI-3 10μM R03 exp144 | -1.7 |
| Pterostilbene 16μM R02 exp78 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12325
- Expression level (log2 read counts): 5.87
Expression Distribution
PABPC1L Expression in NALM6 Cells: 5.87
