UniProt Summary: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}.
Pfam DomainsGO Terms
Pfam Domains
Y phosphatase
GO Terms
phosphotyrosine residue binding
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
protein dephosphorylation
dephosphorylation
endoplasmic reticulum membrane
cellular response to cytokine stimulus
response to cytokine
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)