RAPGEF3
Gene Information
- Official Symbol: RAPGEF3
- Official Name: Rap guanine nucleotide exchange factor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10411
- UniProt: O95398
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho- mediated signaling. Required for the actin rearrangement at cell- cell junctions, such as stress fibers and junctional actin. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:9853756}.
Pfam Domains GO Terms
Pfam Domains
| RasGEF |
| DEP |
| cNMP binding |
| RasGEF N |
GO Terms
| negative regulation of syncytium formation by plasma membrane fusion |
| Rap guanyl-nucleotide exchange factor activity |
| Rap protein signal transduction |
| regulation of histone H3-K9 acetylation |
| positive regulation of protein export from nucleus |
| cAMP binding |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| establishment of endothelial barrier |
| regulation of actin cytoskeleton reorganization |
| regulation of protein export from nucleus |
| positive regulation of protein acetylation |
| endothelial cell development |
| positive regulation of stress fiber assembly |
| cortical actin cytoskeleton |
| cellular response to cAMP |
| regulation of histone acetylation |
| positive regulation of actin filament bundle assembly |
| regulation of peptidyl-lysine acetylation |
| positive regulation of nucleocytoplasmic transport |
| microvillus |
| regulation of protein acetylation |
| filopodium |
| endomembrane system |
| regulation of stress fiber assembly |
| endothelial cell differentiation |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| endothelium development |
| response to cAMP |
| guanyl-nucleotide exchange factor activity |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of nucleocytoplasmic transport |
| response to organophosphorus |
| regulation of peptidyl-serine phosphorylation |
| regulation of histone modification |
| cAMP-mediated signaling |
| response to purine-containing compound |
| positive regulation of intracellular protein transport |
| positive regulation of angiogenesis |
| cyclic-nucleotide-mediated signaling |
| regulation of insulin secretion |
| lamellipodium |
| positive regulation of vasculature development |
| regulation of chromatin organization |
| epithelial cell development |
| positive regulation of supramolecular fiber organization |
| positive regulation of intracellular transport |
| regulation of peptide hormone secretion |
| positive regulation of cytoskeleton organization |
| regulation of intracellular protein transport |
| protein domain specific binding |
| Ras protein signal transduction |
| regulation of actin filament organization |
| regulation of hormone secretion |
| regulation of angiogenesis |
| angiogenesis |
| small GTPase mediated signal transduction |
| regulation of vasculature development |
| positive regulation of cellular protein localization |
| second-messenger-mediated signaling |
| regulation of actin cytoskeleton organization |
| regulation of chromosome organization |
| regulation of supramolecular fiber organization |
| regulation of intracellular transport |
| regulation of actin filament-based process |
| blood vessel morphogenesis |
| positive regulation of GTPase activity |
| positive regulation of protein transport |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of GTPase activity |
| blood vessel development |
| regulation of peptide secretion |
| vasculature development |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| regulation of hormone levels |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| cellular response to organic cyclic compound |
| cellular response to organonitrogen compound |
| positive regulation of organelle organization |
| tube morphogenesis |
| cellular response to nitrogen compound |
| epithelial cell differentiation |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of secretion |
| tube development |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| response to organic cyclic compound |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| regulation of organelle organization |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| cell development |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vinblastine 0.002μM R01 exp60 | -2.23 |
| ETC-159 50μM R08 exp480 | -2.19 |
| UMK57 1μM R01 exp59 | -1.92 |
| ZLN024 50μM R08 exp538 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14828
- Expression level (log2 read counts): 1.05
Expression Distribution
RAPGEF3 Expression in NALM6 Cells: 1.05
