RNF14
Gene Information
- Official Symbol: RNF14
- Official Name: ring finger protein 14
- Aliases and Previous Symbols: N/A
- Entrez ID: 9604
- UniProt: Q9UBS8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RWD |
| IBR |
GO Terms
| ubiquitin-like protein transferase activity |
| regulation of androgen receptor signaling pathway |
| ubiquitin conjugating enzyme binding |
| androgen receptor signaling pathway |
| androgen receptor binding |
| intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular steroid hormone receptor signaling pathway |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| positive regulation of ubiquitin-dependent protein catabolic process |
| positive regulation of proteasomal protein catabolic process |
| ubiquitin ligase complex |
| steroid hormone mediated signaling pathway |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| positive regulation of cellular protein catabolic process |
| regulation of ubiquitin-dependent protein catabolic process |
| intracellular receptor signaling pathway |
| hormone-mediated signaling pathway |
| regulation of proteasomal protein catabolic process |
| cellular response to steroid hormone stimulus |
| positive regulation of protein catabolic process |
| regulation of proteolysis involved in cellular protein catabolic process |
| ubiquitin protein ligase activity |
| regulation of cellular protein catabolic process |
| transcription coactivator activity |
| protein polyubiquitination |
| response to steroid hormone |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of protein catabolic process |
| positive regulation of catabolic process |
| cellular response to lipid |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| cellular response to organic cyclic compound |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular response to hormone stimulus |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| regulation of proteolysis |
| protein modification by small protein conjugation |
| regulation of cellular catabolic process |
| response to lipid |
| cellular macromolecule catabolic process |
| response to hormone |
| response to organic cyclic compound |
| protein modification by small protein conjugation or removal |
| regulation of catabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cellular response to endogenous stimulus |
| proteolysis |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.552 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 11/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3118
- Expression level (log2 read counts): 4.15
Expression Distribution
RNF14 Expression in NALM6 Cells: 4.15
