RRS1
Gene Information
- Official Symbol: RRS1
- Official Name: ribosome biogenesis regulator 1 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 23212
- UniProt: Q15050
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.
Pfam Domains GO Terms
Pfam Domains
| RRS1 |
GO Terms
| protein localization to nucleolus |
| ribosomal large subunit export from nucleus |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| 5S rRNA binding |
| endonucleolytic cleavage involved in rRNA processing |
| endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| ribosome localization |
| ribosomal subunit export from nucleus |
| rRNA-containing ribonucleoprotein complex export from nucleus |
| cleavage involved in rRNA processing |
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| preribosome, large subunit precursor |
| maturation of 5.8S rRNA |
| condensed nuclear chromosome |
| ribosomal large subunit assembly |
| maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| maturation of SSU-rRNA |
| mitotic metaphase plate congression |
| metaphase plate congression |
| ribosome assembly |
| ribosomal small subunit biogenesis |
| ribosomal large subunit biogenesis |
| establishment of chromosome localization |
| chromosome localization |
| RNA phosphodiester bond hydrolysis, endonucleolytic |
| hematopoietic progenitor cell differentiation |
| mitotic sister chromatid segregation |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| RNA export from nucleus |
| fibrillar center |
| sister chromatid segregation |
| mitotic nuclear division |
| protein export from nucleus |
| nuclear export |
| RNA phosphodiester bond hydrolysis |
| protein localization to nucleus |
| regulation of signal transduction by p53 class mediator |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| rRNA processing |
| RNA localization |
| nuclear chromosome segregation |
| rRNA metabolic process |
| ribonucleoprotein complex assembly |
| nucleobase-containing compound transport |
| ribonucleoprotein complex subunit organization |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| nuclear transport |
| chromosome segregation |
| nuclear division |
| nucleic acid phosphodiester bond hydrolysis |
| ribosome biogenesis |
| organelle fission |
| establishment of organelle localization |
| ncRNA processing |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| hemopoiesis |
| organelle localization |
| mitotic cell cycle process |
| hematopoietic or lymphoid organ development |
| immune system development |
| mitotic cell cycle |
| protein localization to organelle |
| organelle assembly |
| cellular protein-containing complex assembly |
| nucleolus |
| RNA processing |
| intracellular protein transport |
| cell cycle process |
| endoplasmic reticulum |
| chromosome organization |
| cell cycle |
| RNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| RNA metabolic process |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Chloramphenicol 2μM R00 exp12 | 1.7 |
| Disulfiram 4.3μM R06 exp281 | 1.82 |
| Momordin-Ic 10μM R08 exp506 | 2.05 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 625/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 20/28 |
| bone | 21/26 |
| breast | 24/33 |
| central nervous system | 52/56 |
| cervix | 3/4 |
| colorectal | 15/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 10/16 |
| kidney | 18/21 |
| liver | 16/20 |
| lung | 62/75 |
| lymphocyte | 14/16 |
| ovary | 25/26 |
| pancreas | 22/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 8/15 |
| prostate | 0/1 |
| skin | 23/24 |
| soft tissue | 7/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 26/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 695
- Expression level (log2 read counts): 5.83
Expression Distribution
RRS1 Expression in NALM6 Cells: 5.83
