SDC4
Gene Information
- Official Symbol: SDC4
- Official Name: syndecan 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6385
- UniProt: P31431
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.
Pfam Domains GO Terms
Pfam Domains
| Syndecan |
GO Terms
| thrombospondin receptor activity |
| positive regulation of extracellular exosome assembly |
| regulation of extracellular exosome assembly |
| positive regulation of exosomal secretion |
| regulation of exosomal secretion |
| costamere |
| positive regulation of focal adhesion assembly |
| fibronectin binding |
| inner ear receptor cell stereocilium organization |
| regulation of fibroblast migration |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| inner ear receptor cell development |
| positive regulation of cell-matrix adhesion |
| positive regulation of stress fiber assembly |
| inner ear receptor cell differentiation |
| protein kinase C binding |
| mechanoreceptor differentiation |
| regulation of cell-substrate junction assembly |
| negative regulation of T cell proliferation |
| regulation of focal adhesion assembly |
| glycosaminoglycan catabolic process |
| positive regulation of actin filament bundle assembly |
| aminoglycan catabolic process |
| regulation of adherens junction organization |
| negative regulation of mononuclear cell proliferation |
| positive regulation of organelle assembly |
| negative regulation of lymphocyte proliferation |
| regulation of stress fiber assembly |
| negative regulation of leukocyte proliferation |
| ureteric bud development |
| mesonephric epithelium development |
| mesonephric tubule development |
| regulation of cell junction assembly |
| positive regulation of exocytosis |
| regulation of actomyosin structure organization |
| mesonephros development |
| neural tube closure |
| tube closure |
| regulation of actin filament bundle assembly |
| lysosomal lumen |
| primary neural tube formation |
| Golgi lumen |
| glycosaminoglycan biosynthetic process |
| retinoid metabolic process |
| neural tube formation |
| aminoglycan biosynthetic process |
| diterpenoid metabolic process |
| negative regulation of T cell activation |
| regulation of cell-matrix adhesion |
| terpenoid metabolic process |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of cell-substrate adhesion |
| embryonic epithelial tube formation |
| kidney epithelium development |
| epithelial tube formation |
| isoprenoid metabolic process |
| morphogenesis of embryonic epithelium |
| negative regulation of lymphocyte activation |
| tube formation |
| glycosaminoglycan metabolic process |
| regulation of T cell proliferation |
| neural tube development |
| aminoglycan metabolic process |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| carbohydrate derivative catabolic process |
| inner ear development |
| negative regulation of cell activation |
| positive regulation of supramolecular fiber organization |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of cell-substrate adhesion |
| positive regulation of cytoskeleton organization |
| regulation of organelle assembly |
| ear development |
| regulation of leukocyte proliferation |
| regulation of exocytosis |
| membrane raft |
| regulation of actin filament organization |
| kidney development |
| negative regulation of cell adhesion |
| renal system development |
| regulation of leukocyte cell-cell adhesion |
| epithelial tube morphogenesis |
| regulation of T cell activation |
| urogenital system development |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| leukocyte migration |
| regulation of actin filament-based process |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| focal adhesion |
| morphogenesis of an epithelium |
| positive regulation of secretion |
| negative regulation of immune system process |
| wound healing |
| regulation of lymphocyte activation |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| sensory organ development |
| regulation of vesicle-mediated transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| cell surface |
| carbohydrate derivative biosynthetic process |
| positive regulation of organelle organization |
| chordate embryonic development |
| regulation of cell activation |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| neuron projection development |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of secretion by cell |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| tube development |
| regulation of cell migration |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| cell migration |
| embryo development |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| identical protein binding |
| localization of cell |
| cell motility |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of protein modification process |
| regulation of organelle organization |
| locomotion |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rotenone 2μM R00 exp33 | -1.79 |
| Cycloheximide 0.02μM R00 exp14 | 1.89 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.685 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15815
- Expression level (log2 read counts): -1.82
Expression Distribution
SDC4 Expression in NALM6 Cells: -1.82
