Entrez Summary: This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate. {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:18327257}.
Pfam DomainsGO Terms
Pfam Domains
MFS 1
Sugar tr
GO Terms
urate transmembrane transporter activity
urate transport
carbohydrate:proton symporter activity
urate metabolic process
glucose transmembrane transporter activity
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
transmembrane transporter activity
carbohydrate transport
proton transmembrane transport
basolateral plasma membrane
apical plasma membrane
purine-containing compound metabolic process
monovalent inorganic cation transport
organic anion transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
organic acid metabolic process
transmembrane transport
ion transport
small molecule metabolic process
nitrogen compound transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)