SRD5A1
Gene Information
- Official Symbol: SRD5A1
- Official Name: steroid 5 alpha-reductase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6715
- UniProt: P18405
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Pfam Domains GO Terms
Pfam Domains
| Steroid dh |
| DUF1295 |
GO Terms
| circadian sleep/wake cycle, REM sleep |
| amide binding |
| cholestenone 5-alpha-reductase activity |
| circadian sleep/wake cycle, sleep |
| 3-oxo-5-alpha-steroid 4-dehydrogenase activity |
| circadian sleep/wake cycle process |
| androgen catabolic process |
| circadian sleep/wake cycle |
| cell body fiber |
| cellular response to testosterone stimulus |
| serotonin metabolic process |
| androgen biosynthetic process |
| response to fungicide |
| progesterone metabolic process |
| thalamus development |
| primary amino compound metabolic process |
| cellular response to epinephrine stimulus |
| sleep |
| NADPH binding |
| response to epinephrine |
| hormone catabolic process |
| response to follicle-stimulating hormone |
| female genitalia development |
| hypothalamus development |
| circadian behavior |
| male genitalia development |
| sex determination |
| rhythmic behavior |
| indole-containing compound metabolic process |
| response to muscle activity |
| androgen metabolic process |
| steroid catabolic process |
| response to gonadotropin |
| C21-steroid hormone metabolic process |
| cellular response to dexamethasone stimulus |
| myelin sheath |
| response to growth hormone |
| cellular response to estradiol stimulus |
| response to testosterone |
| response to dexamethasone |
| pituitary gland development |
| steroid hormone biosynthetic process |
| genitalia development |
| cellular response to cAMP |
| cellular response to glucocorticoid stimulus |
| cellular response to corticosteroid stimulus |
| hormone biosynthetic process |
| response to activity |
| cellular ketone metabolic process |
| diencephalon development |
| response to estrogen |
| electron transfer activity |
| hippocampus development |
| phenol-containing compound metabolic process |
| neurotransmitter metabolic process |
| cellular response to ketone |
| response to antineoplastic agent |
| response to cAMP |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to monoamine |
| response to catecholamine |
| female sex differentiation |
| spinal cord development |
| diterpenoid metabolic process |
| limbic system development |
| cerebral cortex development |
| oxidoreductase activity |
| terpenoid metabolic process |
| cellular hormone metabolic process |
| endocrine system development |
| liver development |
| steroid biosynthetic process |
| hepaticobiliary system development |
| male gonad development |
| development of primary male sexual characteristics |
| response to estradiol |
| response to organophosphorus |
| isoprenoid metabolic process |
| circadian rhythm |
| response to glucocorticoid |
| cellular response to starvation |
| response to purine-containing compound |
| male sex differentiation |
| response to corticosteroid |
| cellular response to insulin stimulus |
| pallium development |
| electron transport chain |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| response to starvation |
| ammonium ion metabolic process |
| response to ketone |
| bone development |
| hormone metabolic process |
| gonad development |
| development of primary sexual characteristics |
| response to insulin |
| cellular response to nutrient levels |
| telencephalon development |
| steroid metabolic process |
| cellular response to extracellular stimulus |
| sex differentiation |
| cellular response to peptide hormone stimulus |
| rhythmic process |
| lipid catabolic process |
| response to xenobiotic stimulus |
| response to antibiotic |
| urogenital system development |
| cellular response to peptide |
| response to steroid hormone |
| cellular response to external stimulus |
| regulation of neurotransmitter levels |
| neuronal cell body |
| forebrain development |
| response to peptide hormone |
| cellular response to drug |
| gland development |
| generation of precursor metabolites and energy |
| reproductive structure development |
| reproductive system development |
| organic hydroxy compound metabolic process |
| response to peptide |
| organic cyclic compound catabolic process |
| skeletal system development |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| drug metabolic process |
| response to toxic substance |
| cellular response to lipid |
| response to extracellular stimulus |
| response to growth factor |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| behavior |
| lipid biosynthetic process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| perinuclear region of cytoplasm |
| brain development |
| head development |
| response to lipid |
| response to hormone |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| central nervous system development |
| response to organonitrogen compound |
| response to drug |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| cellular response to stress |
| small molecule metabolic process |
| organic substance catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK-LSD1 10μM R03 exp123 | -1.95 |
| Dynasore 10μM R04 exp180 | -1.87 |
| Vemurafenib 6.6μM R08 exp434 | -1.81 |
| LLY-283 2.6μM R06 exp290 | -1.74 |
| Benzoate 10000μM R08 exp455 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18909
- Expression level (log2 read counts): 5.15
Expression Distribution
SRD5A1 Expression in NALM6 Cells: 5.15
