Pfam Domains GO Terms
| ADIP |
| regulation of Rac protein signal transduction |
| centriolar satellite |
| intraciliary transport involved in cilium assembly |
| cell leading edge |
| intraciliary transport |
| microtubule-based protein transport |
| protein transport along microtubule |
| centrosome cycle |
| microtubule organizing center organization |
| cell-cell adherens junction |
| ciliary basal body |
| transport along microtubule |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| regulation of Ras protein signal transduction |
| protein domain specific binding |
| protein-containing complex localization |
| microtubule-based movement |
| regulation of small GTPase mediated signal transduction |
| cilium assembly |
| cilium organization |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| microtubule cytoskeleton organization |
| protein-containing complex |
| microtubule-based process |
| organelle assembly |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| regulation of locomotion |
| intracellular protein transport |
| regulation of cellular component movement |
| cell cycle process |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cell cycle |
| protein transport |
| intracellular transport |
| peptide transport |
| movement of cell or subcellular component |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| BI-2536 0.02μM R03 exp96 | -2.04 |
| Celastrol 0.12μM R05 exp225 | -1.94 |
| MK-1775 0.32μM R02 exp75 | 1.79 |
| THZ531 0.11μM R07 exp409 | 1.79 |
| HMS-I2 10μM R06 exp288 | 1.9 |
| THZ531 0.11 to 0.175μM on day4 R07 exp413 | 2.14 |
| IWR1 50μM R08 exp495 | 2.33 |
| Gene | Correlation |
|---|---|
| RRM1 | 0.526 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution