SYT8

Entrez Summary: N/A
UniProt Summary: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aminopterin 0.005μM R07 exp335	-2.06
Adefovir 20μM R07 exp332	-1.96
MS094 2μM R03 exp136	-1.94
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.93
Genistein 15μM R07 exp360	-1.86
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.85
Chlorpromazine 10μM R07 exp344	-1.82
CVT-10216 0.1μM R06 exp278	-1.76
YM155 0.0002μM R01 exp61	1.7
Lapatinib 5μM R01 exp47	1.73
IWR1 50μM R08 exp495	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution