TBC1D20

Entrez Summary: This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
UniProt Summary: GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-2.9
Cerivastatin 0.15μM R05 exp226	-2.25
Golgicide-A 2μM R03 exp121	-2.22
CFI-400945 25μM R08 exp469	-2.09
Dynasore 10μM R04 exp180	-2.02
Fluvastatin 2.2μM R06 exp282	-1.94
Golgicide-A 4μM R03 exp122	-1.93
SB743921 0.001μM R05 exp244	-1.93
UMK57 0.6μM R03 exp107	-1.87
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.76
THZ1 0.06μM R08 exp531	-1.76
TIC10 10μM R08 exp532	1.72
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.75

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution