Entrez Summary: This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Trypsin
DUF1986
GO Terms
scavenger receptor activity
blood microparticle
serine-type endopeptidase activity
endocytosis
import into cell
proteolysis
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)