TNIK
Gene Information
- Official Symbol: TNIK
- Official Name: TRAF2 and NCK interacting kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 23043
- UniProt: Q9UKE5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase |
| Pkinase Tyr |
| CNH |
GO Terms
| activation of JNKK activity |
| microvillus assembly |
| postsynaptic density, intracellular component |
| microvillus organization |
| activation of MAPKK activity |
| actin cytoskeleton reorganization |
| positive regulation of JUN kinase activity |
| JNK cascade |
| regulation of JUN kinase activity |
| regulation of dendrite morphogenesis |
| presynapse |
| stress-activated MAPK cascade |
| recycling endosome |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| regulation of dendrite development |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| protein localization to plasma membrane |
| regulation of JNK cascade |
| protein autophosphorylation |
| protein localization to cell periphery |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| protein kinase activity |
| positive regulation of MAP kinase activity |
| regulation of cell morphogenesis involved in differentiation |
| apical plasma membrane |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| glutamatergic synapse |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| protein serine/threonine kinase activity |
| cytoskeleton |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| actin filament-based process |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of kinase activity |
| regulation of nervous system development |
| regulation of cell development |
| protein phosphorylation |
| regulation of transferase activity |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6795
- Expression level (log2 read counts): -2.84
Expression Distribution
TNIK Expression in NALM6 Cells: -2.84
