TUBGCP4
Gene Information
- Official Symbol: TUBGCP4
- Official Name: tubulin gamma complex associated protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 27229
- UniProt: Q9UGJ1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
- UniProt Summary: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1619
- Expression level (log2 read counts): 7.07
TUBGCP4 Expression in NALM6 Cells: 7.07
