Pfam Domains GO Terms
| dihydroceramide glucosyltransferase activity |
| ceramide glucosyltransferase activity |
| glucosylceramide biosynthetic process |
| cornified envelope assembly |
| glycosylceramide biosynthetic process |
| glucosylceramide metabolic process |
| leptin-mediated signaling pathway |
| intestinal lipid absorption |
| cellular response to leptin stimulus |
| glycosylceramide metabolic process |
| response to leptin |
| establishment of skin barrier |
| glycosphingolipid biosynthetic process |
| regulation of water loss via skin |
| intestinal absorption |
| membrane assembly |
| membrane biogenesis |
| ceramide biosynthetic process |
| glycosphingolipid metabolic process |
| glycolipid biosynthetic process |
| multicellular organismal water homeostasis |
| water homeostasis |
| digestive system process |
| ceramide metabolic process |
| protein lipidation |
| lipoprotein biosynthetic process |
| sphingolipid biosynthetic process |
| plasma membrane organization |
| glycolipid metabolic process |
| liposaccharide metabolic process |
| digestion |
| lipoprotein metabolic process |
| membrane lipid biosynthetic process |
| sphingolipid metabolic process |
| membrane lipid metabolic process |
| keratinocyte differentiation |
| lipid transport |
| epidermal cell differentiation |
| lipid localization |
| multicellular organismal homeostasis |
| skin development |
| epidermis development |
| endomembrane system organization |
| regulation of body fluid levels |
| amide biosynthetic process |
| lipid biosynthetic process |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| Golgi membrane |
| cytokine-mediated signaling pathway |
| epithelial cell differentiation |
| cellular amide metabolic process |
| neuron development |
| membrane organization |
| response to hormone |
| cellular lipid metabolic process |
| cellular response to cytokine stimulus |
| neuron differentiation |
| carbohydrate derivative metabolic process |
| response to cytokine |
| chemical homeostasis |
| epithelium development |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| generation of neurons |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cell development |
| cellular macromolecule biosynthetic process |
| tissue development |
| macromolecule biosynthetic process |
| system process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -3.65 |
| Monensin 0.3μM R08 exp507 | -3.31 |
| Vemurafenib 6.6μM R02 exp89 | -3.09 |
| Brefeldin A 0.02μM R00 exp8 | -2.93 |
| PFI-3 10μM R03 exp144 | -1.76 |
| Deguelin 0.05μM R02 exp69 | -1.73 |
| Azithromycin 100μM R08 exp452 | -1.71 |
| NMS-873 0.07μM R07 exp380 | 1.73 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution