VIPAS39
Gene Information
- Official Symbol: VIPAS39
- Official Name: VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
- Aliases and Previous Symbols: N/A
- Entrez ID: 63894
- UniProt: Q9H9C1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
- UniProt Summary: Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A- dependent recycling pathway and in the maintenance of the apical- basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E- cadherin (By similarity). {ECO:0000250|UniProtKB:Q23288, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:20190753}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14332
- Expression level (log2 read counts): 4.56
VIPAS39 Expression in NALM6 Cells: 4.56
