WNT3A
Gene Information
- Official Symbol: WNT3A
- Official Name: Wnt family member 3A
- Aliases and Previous Symbols: N/A
- Entrez ID: 89780
- UniProt: P56704
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). {ECO:0000250|UniProtKB:P27467, ECO:0000269|PubMed:20093360, ECO:0000269|PubMed:21244856, ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720, ECO:0000305}.
Pfam Domains GO Terms
Pfam Domains
| wnt |
GO Terms
| positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation |
| regulation of cardioblast cell fate specification |
| negative regulation of cardioblast cell fate specification |
| calcium ion transmembrane transport via low voltage-gated calcium channel |
| negative regulation of cardiac cell fate specification |
| positive regulation of mesodermal cell differentiation |
| positive regulation of mesodermal cell fate specification |
| negative regulation of heart induction by canonical Wnt signaling pathway |
| positive regulation of mesoderm formation |
| Wnt signaling pathway involved in forebrain neuroblast division |
| negative regulation of heart induction |
| regulation of heart induction by canonical Wnt signaling pathway |
| negative regulation of cardioblast differentiation |
| positive regulation of cell fate specification |
| paraxial mesodermal cell differentiation |
| canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| regulation of cardiac cell fate specification |
| regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation |
| paraxial mesodermal cell fate commitment |
| positive regulation of collateral sprouting in absence of injury |
| positive regulation of dermatome development |
| canonical Wnt signaling pathway involved in heart development |
| negative regulation of dopaminergic neuron differentiation |
| regulation of collateral sprouting in absence of injury |
| Wnt-Frizzled-LRP5/6 complex |
| axis elongation involved in somitogenesis |
| regulation of dermatome development |
| positive regulation of mesoderm development |
| COP9 signalosome assembly |
| Wnt signaling pathway involved in heart development |
| cell proliferation in midbrain |
| regulation of heart induction |
| negative regulation of cell fate specification |
| cardiac muscle cell fate commitment |
| paraxial mesoderm formation |
| regulation of mesodermal cell differentiation |
| positive regulation of core promoter binding |
| regulation of mesodermal cell fate specification |
| regulation of mesoderm formation |
| regulation of core promoter binding |
| regulation of cardioblast differentiation |
| positive regulation of hepatocyte proliferation |
| positive regulation of gastrulation |
| forebrain neuroblast division |
| positive regulation of cell fate commitment |
| postsynapse to nucleus signaling pathway |
| paraxial mesoderm morphogenesis |
| regulation of dopaminergic neuron differentiation |
| cardiac cell fate commitment |
| Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| positive regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of collateral sprouting |
| midbrain dopaminergic neuron differentiation |
| regulation of cell fate specification |
| negative regulation of cell fate commitment |
| co-receptor binding |
| regulation of type B pancreatic cell proliferation |
| mesodermal cell fate commitment |
| regulation of hepatocyte proliferation |
| spinal cord association neuron differentiation |
| muscle cell fate commitment |
| neuroblast division |
| neuronal stem cell division |
| dorsal/ventral neural tube patterning |
| regulation of mesoderm development |
| regulation of cell-cell adhesion mediated by cadherin |
| paraxial mesoderm development |
| post-anal tail morphogenesis |
| presynapse assembly |
| positive regulation of cardiac muscle cell differentiation |
| regulation of collateral sprouting |
| negative regulation of stem cell differentiation |
| beta-catenin destruction complex disassembly |
| negative regulation of cardiocyte differentiation |
| presynapse organization |
| dorsal spinal cord development |
| somatic stem cell division |
| cell surface receptor signaling pathway involved in heart development |
| secondary palate development |
| positive regulation of receptor internalization |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of skeletal muscle tissue development |
| negative regulation of axon extension involved in axon guidance |
| mesodermal cell differentiation |
| axis elongation |
| cell proliferation in forebrain |
| cell fate commitment involved in formation of primary germ layer |
| negative regulation of axon guidance |
| regulation of cell fate commitment |
| positive regulation of cardiocyte differentiation |
| regulation of presynapse assembly |
| regulation of presynapse organization |
| dopaminergic neuron differentiation |
| neuroblast proliferation |
| regulation of axon extension involved in axon guidance |
| stem cell division |
| receptor ligand activity |
| neural tube patterning |
| regulation of cardiac muscle cell differentiation |
| regulation of animal organ formation |
| positive regulation of embryonic development |
| regulation of gastrulation |
| postsynaptic signal transduction |
| frizzled binding |
| regulation of heart morphogenesis |
| positive regulation of B cell proliferation |
| negative regulation of axon extension |
| positive regulation of cardiac muscle tissue development |
| regulation of axon guidance |
| platelet aggregation |
| negative regulation of fat cell differentiation |
| regulation of skeletal muscle tissue development |
| skeletal muscle cell differentiation |
| mesenchyme morphogenesis |
| regulation of cardiocyte differentiation |
| synaptic vesicle recycling |
| positive regulation of receptor-mediated endocytosis |
| regulation of transcription regulatory region DNA binding |
| positive regulation of neural precursor cell proliferation |
| stem cell proliferation |
| cell differentiation in spinal cord |
| regulation of receptor internalization |
| positive regulation of protein localization to plasma membrane |
| positive regulation of protein tyrosine kinase activity |
| positive regulation of DNA binding |
| negative regulation of chemotaxis |
| positive regulation of striated muscle cell differentiation |
| homotypic cell-cell adhesion |
| heart looping |
| regulation of B cell proliferation |
| positive regulation of protein localization to cell periphery |
| somitogenesis |
| determination of heart left/right asymmetry |
| embryonic heart tube morphogenesis |
| forebrain generation of neurons |
| mesoderm formation |
| endocytic vesicle membrane |
| negative regulation of axonogenesis |
| mesoderm morphogenesis |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| cellular response to retinoic acid |
| positive regulation of muscle tissue development |
| neural precursor cell proliferation |
| embryonic heart tube development |
| regulation of cardiac muscle tissue development |
| positive regulation of animal organ morphogenesis |
| hippocampus development |
| dorsal/ventral pattern formation |
| somite development |
| midbrain development |
| positive regulation of axonogenesis |
| positive regulation of muscle cell differentiation |
| cardiac muscle cell differentiation |
| regulation of neural precursor cell proliferation |
| regulation of protein tyrosine kinase activity |
| canonical Wnt signaling pathway |
| roof of mouth development |
| synapse assembly |
| positive regulation of protein binding |
| presynapse |
| regulation of protein localization to plasma membrane |
| segmentation |
| regulation of axon extension |
| negative regulation of cell morphogenesis involved in differentiation |
| inner ear morphogenesis |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| Golgi lumen |
| regulation of striated muscle cell differentiation |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of synapse assembly |
| negative regulation of developmental growth |
| spinal cord development |
| response to retinoic acid |
| limbic system development |
| regulation of extent of cell growth |
| formation of primary germ layer |
| developmental growth involved in morphogenesis |
| regulation of protein localization to cell periphery |
| cardiocyte differentiation |
| regulation of stem cell differentiation |
| ear morphogenesis |
| determination of left/right symmetry |
| synaptic vesicle cycle |
| regulation of fat cell differentiation |
| positive regulation of protein localization to membrane |
| skeletal muscle tissue development |
| determination of bilateral symmetry |
| specification of symmetry |
| mesoderm development |
| regulation of DNA binding |
| osteoblast differentiation |
| mammary gland development |
| regulation of embryonic development |
| vesicle-mediated transport in synapse |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| regulation of striated muscle tissue development |
| skeletal muscle organ development |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| positive regulation of leukocyte proliferation |
| regulation of peptidyl-serine phosphorylation |
| platelet activation |
| positive regulation of canonical Wnt signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| early endosome membrane |
| regulation of muscle cell differentiation |
| negative regulation of neuron projection development |
| positive regulation of cell morphogenesis involved in differentiation |
| gastrulation |
| neural tube development |
| cardiac muscle tissue development |
| positive regulation of cell growth |
| positive regulation of B cell activation |
| positive regulation of developmental growth |
| positive regulation of endopeptidase activity |
| pallium development |
| positive regulation of Wnt signaling pathway |
| positive regulation of binding |
| central nervous system neuron differentiation |
| regulation of cell size |
| negative regulation of cell projection organization |
| negative regulation of cell growth |
| regulation of axonogenesis |
| positive regulation of epithelial cell proliferation |
| regulation of protein localization to membrane |
| regulation of microtubule cytoskeleton organization |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of peptidase activity |
| inner ear development |
| calcium ion transmembrane transport |
| striated muscle cell differentiation |
| regulation of endocytosis |
| negative regulation of neuron death |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| cellular response to acid chemical |
| regulation of mononuclear cell proliferation |
| regulation of chemotaxis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| anterior/posterior pattern specification |
| regulation of synapse organization |
| regulation of protein binding |
| ear development |
| mesenchyme development |
| regulation of leukocyte proliferation |
| regulation of microtubule-based process |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| protein-containing complex disassembly |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of growth |
| protein domain specific binding |
| muscle cell differentiation |
| cell fate commitment |
| calcium ion transport |
| heart morphogenesis |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| telencephalon development |
| positive regulation of growth |
| axon guidance |
| positive regulation of DNA-binding transcription factor activity |
| ossification |
| neuron projection guidance |
| synapse organization |
| positive regulation of neuron projection development |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| blood coagulation |
| coagulation |
| muscle organ development |
| divalent metal ion transport |
| muscle tissue development |
| hemostasis |
| divalent inorganic cation transport |
| endoplasmic reticulum lumen |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| regulation of neuron death |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| positive regulation of cellular protein localization |
| regulation of developmental growth |
| regionalization |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| signaling receptor binding |
| extracellular matrix organization |
| response to acid chemical |
| glutamatergic synapse |
| Wnt signaling pathway |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| positive regulation of lymphocyte activation |
| regulation of Wnt signaling pathway |
| negative regulation of response to external stimulus |
| positive regulation of neuron differentiation |
| axonogenesis |
| in utero embryonic development |
| regulation of binding |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| extracellular structure organization |
| forebrain development |
| developmental growth |
| growth |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| axon development |
| gland development |
| regulation of cell growth |
| regulation of endopeptidase activity |
| positive regulation of cell activation |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of DNA-binding transcription factor activity |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| synaptic signaling |
| positive regulation of neurogenesis |
| muscle structure development |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| cell division |
| regulation of neuron projection development |
| regulation of body fluid levels |
| cell-cell adhesion |
| regulation of lymphocyte activation |
| cell part morphogenesis |
| regulation of anatomical structure size |
| cellular response to lipid |
| heart development |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| sensory organ development |
| chemotaxis |
| regulation of vesicle-mediated transport |
| taxis |
| cell population proliferation |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| inorganic cation transmembrane transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| positive regulation of kinase activity |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cation transmembrane transport |
| cell surface |
| chordate embryonic development |
| metal ion transport |
| regulation of cell activation |
| positive regulation of apoptotic process |
| inorganic ion transmembrane transport |
| immune system development |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| neuron projection development |
| regulation of growth |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of proteolysis |
| brain development |
| positive regulation of hydrolase activity |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| cation transport |
| cellular protein-containing complex assembly |
| tube development |
| response to lipid |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| ion transmembrane transport |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| regulation of response to external stimulus |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| transmembrane transport |
| regulation of hydrolase activity |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| ion transport |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13470
- Expression level (log2 read counts): -4.6
Expression Distribution
WNT3A Expression in NALM6 Cells: -4.6
