ACAA1
Gene Information
- Official Symbol: ACAA1
- Official Name: acetyl-CoA acyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 30
- UniProt: P09110
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Thiolase N |
| Thiolase C |
GO Terms
| acetate CoA-transferase activity |
| auxin catabolic process |
| phenylacetate catabolic process |
| auxin metabolic process |
| palmitoyl-CoA oxidase activity |
| toxin catabolic process |
| acetyl-CoA C-acyltransferase activity |
| xenobiotic catabolic process |
| alpha-linolenic acid metabolic process |
| fatty acid beta-oxidation using acyl-CoA oxidase |
| hormone catabolic process |
| toxin metabolic process |
| benzene-containing compound metabolic process |
| very long-chain fatty acid metabolic process |
| bile acid metabolic process |
| peroxisomal matrix |
| secondary metabolic process |
| fatty acid beta-oxidation |
| specific granule lumen |
| protein localization to peroxisome |
| protein targeting to peroxisome |
| establishment of protein localization to peroxisome |
| peroxisomal transport |
| fatty acid oxidation |
| lipid oxidation |
| peroxisome organization |
| fatty acid catabolic process |
| unsaturated fatty acid metabolic process |
| peroxisome |
| long-chain fatty acid metabolic process |
| monocarboxylic acid catabolic process |
| detoxification |
| xenobiotic metabolic process |
| cellular response to xenobiotic stimulus |
| cellular lipid catabolic process |
| lipid modification |
| hormone metabolic process |
| steroid metabolic process |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| lipid catabolic process |
| response to xenobiotic stimulus |
| fatty acid metabolic process |
| protein targeting |
| establishment of protein localization to organelle |
| small molecule catabolic process |
| aromatic compound catabolic process |
| organic hydroxy compound metabolic process |
| organic cyclic compound catabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| drug metabolic process |
| neutrophil activation |
| granulocyte activation |
| response to toxic substance |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| monocarboxylic acid metabolic process |
| regulation of hormone levels |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| intracellular membrane-bounded organelle |
| regulated exocytosis |
| protein localization to organelle |
| leukocyte mediated immunity |
| exocytosis |
| carboxylic acid metabolic process |
| leukocyte activation |
| cellular lipid metabolic process |
| oxidation-reduction process |
| intracellular protein transport |
| oxoacid metabolic process |
| secretion by cell |
| organic acid metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| secretion |
| lipid metabolic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ethanol 0.01 R05 exp234 | 1.72 |
| UM0011500 10μM R05 exp246 | 1.76 |
| Mubritinib 0.2μM R02 exp65 | 1.79 |
| Fluvastatin 2.2μM R06 exp282 | 1.94 |
| Cerivastatin 0.15μM R05 exp226 | 2.32 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ACSL3 | 0.407 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13118
- Expression level (log2 read counts): 5.34
Expression Distribution
ACAA1 Expression in NALM6 Cells: 5.34
