ACTR1B
Gene Information
- Official Symbol: ACTR1B
- Official Name: actin related protein 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 10120
- UniProt: P42025
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Pfam Domains GO Terms
Pfam Domains
| Actin |
GO Terms
| microtubule cortical anchor activity |
| nuclear migration along microtubule |
| dynactin complex |
| cell cortex region |
| nuclear migration |
| nucleus localization |
| establishment of mitotic spindle orientation |
| establishment of mitotic spindle localization |
| establishment of spindle orientation |
| establishment of spindle localization |
| spindle localization |
| organelle transport along microtubule |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| microtubule cytoskeleton organization involved in mitosis |
| secretory granule lumen |
| establishment of cell polarity |
| ficolin-1-rich granule lumen |
| microtubule cytoskeleton |
| transport along microtubule |
| cytoskeleton-dependent intracellular transport |
| antigen processing and presentation of exogenous peptide antigen |
| microtubule-based transport |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| establishment or maintenance of cell polarity |
| antigen processing and presentation |
| microtubule-based movement |
| establishment of organelle localization |
| microtubule cytoskeleton organization |
| neutrophil degranulation |
| centrosome |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| organelle localization |
| myeloid leukocyte activation |
| mitotic cell cycle process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| microtubule-based process |
| mitotic cell cycle |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| leukocyte activation |
| cell cycle process |
| secretion by cell |
| export from cell |
| cell activation |
| immune effector process |
| cytoskeleton organization |
| secretion |
| cell cycle |
| ATP binding |
| intracellular transport |
| movement of cell or subcellular component |
| establishment of localization in cell |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK461364A 0.005μM R03 exp125 | -2.93 |
| BI-2536 0.0042μM R03 exp95 | -2.69 |
| Vincristine 0.0005μM R04 exp190 | -2.48 |
| BI-6727 0.0125μM R03 exp97 | -2.03 |
| Colchicine 0.009μM R05 exp215 | -1.82 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| KIF18A | 0.416 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6982
- Expression level (log2 read counts): 5.67
Expression Distribution
ACTR1B Expression in NALM6 Cells: 5.67
