Pfam Domains GO Terms
| 7tm 1 |
| 7TM GPCR Srsx |
| alpha1-adrenergic receptor activity |
| norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure |
| neuron-glial cell signaling |
| positive regulation of blood pressure by epinephrine-norepinephrine |
| regulation of systemic arterial blood pressure by norepinephrine-epinephrine |
| adrenergic receptor activity |
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| adrenergic receptor signaling pathway |
| positive regulation of smooth muscle contraction |
| vasoconstriction |
| positive regulation of vasoconstriction |
| positive regulation of blood pressure |
| negative regulation of blood vessel diameter |
| positive regulation of muscle contraction |
| regulation of systemic arterial blood pressure mediated by a chemical signal |
| regulation of vasoconstriction |
| regulation of smooth muscle contraction |
| positive regulation of blood circulation |
| caveola |
| regulation of cardiac muscle contraction |
| regulation of striated muscle contraction |
| regulation of systemic arterial blood pressure |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| cAMP-mediated signaling |
| regulation of muscle contraction |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| regulation of blood pressure |
| glucose homeostasis |
| carbohydrate homeostasis |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of muscle system process |
| nuclear membrane |
| regulation of heart contraction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| regulation of cytosolic calcium ion concentration |
| second-messenger-mediated signaling |
| blood circulation |
| circulatory system process |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of anatomical structure size |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| cellular homeostasis |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| G protein-coupled receptor signaling pathway |
| integral component of plasma membrane |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Chloramphenicol 20μM R00 exp13 | -1.97 |
| Ethambutol 25μM R08 exp481 | -1.86 |
| LLY-284 2.6μM R06 exp291 | -1.83 |
| ML-792 0.2μM R08 exp505 | -1.73 |
| Chlorpromazine 10μM R07 exp344 | 1.82 |
| GSK2606414 1μM R05 exp236 | 1.84 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution